These days, the desire for naturally occurring antioxidants has significantly\nincreased, especially for use in foodstuffs, cosmetics, and pharmaceutical products, to replace\nsynthetic antioxidants that are regularly constrained due to their carcinogenicity. Methods: The study\nin hand aimed to appraise the antioxidant effect of two Euphorbia dendroides extracts using reducing\npower, anti-peroxidation, and DPPH (1,1 Diphenyl 2 Pycril Hydrazil) scavenging essays, in addition\nto the anticancer activity against two tumor cell lines, namely C6 (rat brain tumor)cells, and Hela\n(human uterus carcinoma)cell lines. Results: The results indicated that the ethyl acetate extract\nexhibited antiradical activity of 29.49%, higher than that of n-butanol extract (18.06%) at 100 �¼g/mL\nbut much lower than that of gallic acid (78.21%).The ethyl acetate extract exhibits better reducing\ncapacity and lipid peroxidation inhibitory activity compared to n-butanol extract but less than\nall tested standards. Moreover, the ethyl acetate extract was found to have an antiproliferative\nactivity of more than 5-FU (5-fluoro-Uracil) against C6 cells at 250 �¼g/mL with IC50 and IC75 of\n113.97, 119.49 �¼g/mL, respectively, and good cytotoxic activity against the Hela cell lines at the same\nconcentration. The HPLC-TOF-MS (high performance liquid chromatography-Time-of-flight-Mass\nSpectrometry) analyses exposed the presence of various compounds, among which Gallic and\nChlorogenic acids functioned as major compounds. Conclusions: The two extracts exhibited\nmoderate anticancer abilities and behaved somewhat as average antioxidant agents. Based on the total\nphenolics and flavonoids contents, as well as HPLC results, it could be concluded that antiproliferative\nand antioxidant activities depend upon the content of different phenolics and flavonoids.
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